Factors Secreted by Human Neuroblastoma Mediate Doxorubicin Resistance by Activating STAT3 and Inhibiting Apoptosis
نویسندگان
چکیده
منابع مشابه
Factors secreted by human neuroblastoma mediated doxorubicin resistance by activating STAT3 and inhibiting apoptosis.
BACKGROUND The transcription factor Stat3 has been reported to play a key role in protecting cells against apoptosis by up-regulating expression of the anti-apoptotic gene BCl-xL. This investigation analyzes the relationship between the development of resistance to doxorubicin-mediated apoptosis in neuroblastoma cells (SKN-SH) and activation of the Stat3 signaling pathway. MATERIALS AND METHO...
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ژورنال
عنوان ژورنال: Molecular Medicine
سال: 2001
ISSN: 1076-1551,1528-3658
DOI: 10.1007/bf03402185